We are seeking two scientists to join our team of Mathematical Immunologists at Imperial College London under the guidance of Prof Becca Asquith. We will consider applications at both postdoc or postgrad level, postgrads may be eligible to do a PhD.

You will work on an interdisciplinary project, funded by the Wellcome Trust, which is a collaboration between theorists, clinicians and experimental immunologists. The aim of the project is to understand the fundamental immunobiology of “unconventional” (γδ) T cells in humans.

Your role will be to develop novel models and approaches to analyse and interpret new experimental data using a range of theoretical techniques (including ordinary differential equation modelling, multivariate regression, and frequentist and/or Bayesian parameter inference).

T cell immunology has revolutionised clinical therapeutics. The overwhelming majority of our knowledge of T cells is restricted to classical (“αβ”) T cells, in comparison we know almost nothing about unconventional (“γδ”) T cells: this represents an untapped resource and a huge knowledge gap. This project will investigate how γδ T cells balance production, proliferation, death and differentiation to maintain a functioning, protective population with appropriate T cell receptor repertoire diversity.