The South African Centre for Epidemiological Modelling & Analysis (SACEMA) is a national research centre based at Stellenbosch University. SACEMA was established in 2006 under the Centres of Excellence programme of the Department of Science and Technology and the National Research Foundation. Our core mission is to improve health in South Africa and across the continent through model-based analysis. Trained in mathematics, biology, physics, economics, statistics, and epidemiology, our researchers bridge disciplines to understand disease dynamics and improve real-world outcomes. Over the past 10 years, SACEMA has developed a robust and impactful research program in quantitative infectious disease epidemiology. Our current research falls under two broad themes: at the scale of individual patients, we work on biomarkers, drug targets, and diagnostics, and at the population scale, we focus on transmission, dynamics, and interventions. SACEMA Postdoctoral Fellows are supported for up to three years to develop work of mutual interest.