In order to substantially reduce the global TB burden, additional control interventions are urgently required. Identifying modifiable factors which risk of progression to TB could lead to innovative interventions to curtail the epidemic. The public health benefit of identifying common viral infections, such as influenza, which increase the risk of TB, and which can be targeted with vaccine interventions, may be substantial. For the first phase of the PhD, the student will use curated datasets from the Western Cape Provincial Health Data Centre to investigate the association between influenza and tuberculosis using 2 different study designs. During the second phase, the student will develop and calibrate a mathematical model of tuberculosis and influenza transmission in South Africa, incorporating the impact of influenza on risk of developing TB. They will model different levels of influenza vaccine coverage in different risk groups, and estimate the impact on TB incidence and mortality.